Birth weight and adult lung function in China [4]

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Long-term morbidity from severe pneumonia in early childhood in The Gambia, West Africa: a follow-up study

OBJECTIVE: To assess long-term outcomes in severe early childhood pneumonia in The Gambia. DESIGN: Observational cohort study of children hospitalised with severe pneumonia between 1992 and 1 04 compared to age, sex, and neigh bourhood-marched controls on measures of current general and pulmonary health. RESULTS: Of 83 children successfully traced, 68 of the 69 alive at follow-up agreed to participate. Thirteen per Cent of cases and 4% of controls had lung disease clinically or on spirometry. Another 16 (13%) participants had abnormal spirometry but did not meet the American Thoracic Society technical criteria (formally 'inconclusive'). Odds ratios of lung disease among childhood pneumonia cases were 2.93 (95 %CI 0.69-12.48, P = 0.1468) with incon-clusives omitted; 2.53 (95 %CI 0.61-10.59, P = 0.2033) with inconclusives included as normal; and 2.83 (95%CI 1.09-7.36, P = 0.0334) with inconclusives included as lung disease. Among deceased cases, most deaths were reported within weeks of discharge, suggesting a possible connection between admission and subsequent death. CONCLUSION: These African data, while not conclusive, add to previous data suggesting a link between severe early, childhood pneumonia and later chronic lung disease. While larger-scale research is needed, increased awareness of possible long-term morbidity in children with severe pneumonia is warranted to limit its impact and optimise long-term health

Advantages of Blood Pressure Optimisation Study

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TRUNCATE-TB: an innovative trial design for drug-sensitive tuberculosis

Background: The number of potential regimens of drug treatment for TB is vast, meaning that evaluating each new treatment against a control in separate two-arm trials requires a huge amount of resources. There is, therefore, a need for innovative trial designs that can evaluate drug regimens simultaneously

Urotensin II in hypertension

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Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance

We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and β-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance. © 2006 Elsevier Inc. All rights reserved.postprin

Do unsaturated fatty acids have beneficial effect on reduction of stroke risk in hypertensive population?

Abstracts for Chaired Posters: no. CP10BACKGROUND: It has been suggested that monospecific unsaturated fatty acids have potential effect on protection against stroke. Studies on the effect of different categories of fatty acids are lacking. The stroke incidence is high in hypertensive patients. Therefore, we studied the relationship between serum level of 6 categories of fatty acids and stroke incidence in ...postprin

Human foot three-dimensional finite element of modeling and its biomechanical applications

2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe